Infant Pain Vs. Pain with Parental Suppression: Immediate and Enduring Impact on Brain, Pain and Affect

Pain experienced within a social context impacts infant neurobehavioral responses and initiates an altered developmental trajectory of pain and affect processing that diverges from experiencing pain alone. We used microarrays to detail the gene expression following pain with and without the mother at different preweaning ages Pups at PN 8 or PN12 were given very mild tail shocks or were controls with or without the mother and the amygdala dissected at assayed for gene expression