Sean McGuffee, Adrian Elcock (2011) CIL:28235, Escherichia coli. CIL. Dataset

This simulation shows a dynamic molecular model of the bacterial cytoplasm, giving us a spectacular glimpse of the crowded conditions of the interior of a cell over a brief 15-microsecond time span. The model includes 50 of the most abundant types of macromolecules reported in Escherichia coli, for a total concentration of 275g/L.

This "steric energy" simulation shows a model of macromolecular diffusion based on Brownian dynamics and steric interactions between the molecules. This can be compared the the "full energy" model that also includes electrostatic and hydrophobic interactions.

本模拟呈现了一幅细菌细胞质动态分子模型的图景，在短短15微秒的时间跨度内，为我们揭示了细胞内部拥挤环境的壮丽景象。模型中包含了在埃希氏菌中报道的50种最丰富的宏分子类型，总浓度为275克/升。该“立体能”模拟展示了基于布朗运动和分子间立体相互作用的宏分子扩散模型。这一模型可与包含静电和疏水相互作用的“全能量”模型进行对比。