Transcriptional and interactome network analyses of Substantia Nigra in progressive stages of Parkinson’s disease. Homo sapiens

We analyzed the transcriptomic profile of post-mortem substantia nigra explants from controls, intermediate - Braak 3 (BK3) and 4 (BK4) - stages of Parkinson’s disease in order to investigate how gene-gene interaction patterns vary along disease development. The comparative transcriptional networks analyses indicate that the main hubs in CT network showed less gene-gene connections in BK3 and BK4 networks, probably reflecting changes in SN cell metabolism, population and density along PD stages. Overall design: Substantia nigra transcriptomic profiles of controls and intermediate stages of Parkinson’s disease were compared using ANOVA in order to identify differentially expressed transcripts