Inhibition or genetic deletion of poly(ADP-ribose) polymerase-1 (PARP-1) is profoundly protective against a number of toxic insults in many organ systems1,2. In the brain the molecular mechanisms unde
Croton yanhuii (Family Euphorbiaceae) is an annual aromatic plant endemic to Yunnan Province, China, which yields an aromatic, spicy oil used as a flavoring and fragrance. The aim of the present study
BackgroundIntestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue
The development of clinical stroke therapies remains elusive. The neuroprotective efficacies of thousands of molecules and compounds have not yet been determined; however, screening large volumes of p
