首页/数据集/Additional file 8 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

Additional file 8 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

NIAID Data Ecosystem2026-05-01 收录

数据链接：

https://figshare.com/articles/dataset/Additional_file_8_of_MRE11_p_K464R_mutation_mediates_olaparib_resistance_by_enhancing_DNA_damage_repair_in_HGSOC/24209259 数据链接链接失效反馈

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资源简介：

Supplementary Material 8

应用场景：

创建时间：

2023-09-27

冷冻电镜结构解析

DNA损伤修复机制

Cryo-EM structure of the RecBCD Chi recognised complex Descriptor: DNA fork substrate, RecBCD enzyme subunit RecB, RecBCD enzyme subunit RecC, ... Authors: Cheng, K, Wilkinson, M, Wigley, D.B. Deposit

Protein Data Bank Japan2024-05-22 更新110

PARPi resistance-related RNA expression

PARP抑制剂耐药机制

RNA调控网络分析

Ovarian cancer (OC) is the common gynecological malignancy in women. PARP inhibitors (PARPi) have been approved for ovarian cancer treatment, especially for BRCA-deficient patients. However, the prima

NIAID Data Ecosystem80

DDR inhibition by E4orf4 is PP2A-dependent.

DNA损伤修复机制

磷酸化蛋白质相互作用

(A) L11 cells in which a PP2A-B55 shRNA can be transiently expressed following Dox induction were induced with Dox (+) or left untreated (-). 48 hrs later, the cells were transfected with an empty vec

Figshare2016-03-16 更新70

Harnessing STING Signaling and Natural Killer Cells to overcome PARP Inhibitor Resistance in Homologous Recombination Repair altered Breast Cancer [RNA-seq]

PARP抑制剂耐药机制

肿瘤免疫治疗

Homologous recombination deficiency (HRD) contributes to genomic instability and leads to sensitivity to poly ADP-ribose polymerase inhibitors (PARPi). HRD also activates the cyclic GMPâAMP synthase

NIAID Data Ecosystem90

Transcriptional effects of CSB and the CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells. Homo sapiens

转录组学分析

DNA损伤修复机制

Cockayne syndrome is a segmental progeria most often caused by mutations in the CSB gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR). Over 43 Mya before marmoset

NIAID Data Ecosystem80

Additional file 8 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

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