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Transcriptome analysis of 16HBE cell line models harbouring homozygous Cystic Fibrosis causing mutations. CF model transcriptomes

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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB46396
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The aim of this study was to generate a comparative overview of the impact of different CF-causing mutations on the transcriptome of human bronchial epithelial cells (16HBE14o-). For this purpose, we performed paired-end Illumina mRNA-Seq from total RNA samples isolated from WT and CRISPR gene edited cell lines carrying different homozygous CFTR mutations (F508del, N1303K, G551D and I1234V), using three independent biological replicates.
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2022-01-05
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