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p53 prohibits propagation of chromosome segregation errors that produce structural aneupoidies

NIAID Data Ecosystem2026-05-25 收录

染色体调控

肿瘤抑制机制

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP107070 数据链接链接失效反馈

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资源简介：

We have induced aneuploidies in untransformed human cells to explore how cells deal with an altered chromosome content.

应用场景：

创建时间：

2018-06-01

肿瘤抑制机制

铁死亡调控

The tumor suppressor protein p53 suppresses cancer by regulating processes such as apoptosis, cell cycle arrest, senescence, and ferroptosis. Whereas numerous p53 target genes have been identified, o

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Manipulating the 3D organization of the largest synthetic yeast chromosome [WGS]

基因组设计

染色体调控

Whether synthetic genomescan power life has attracted broad interest in the synthetic biology field, especially when the synthetic genomes are extensively modified with thousands of designer features.

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Hippo Pathway Phylogenetics Predicts Monoubiquitylation of Salvador and Merlin/Nf2

Hippo信号通路调控

肿瘤抑制机制

Recently we employed phylogenetics to predict that the cellular interpretation of TGF-β signals is modulated by monoubiquitylation cycles affecting the Smad4 signal transducer/tumor suppressor. This p

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Condensin chromatin association is regulated by the combined actions of SMC head and hinge engagement and phosphorylation

染色体调控

磷酸化机制

The SMC condensin complex is essential for normal mitotic chromosome structure in eukaryotes. Here we undertake a comprehensive analysis of the importance of the condensin ATP binding and hydrolysis,

NIAID Data Ecosystem50

Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation.

染色体调控

染色质构象

Condensin is a conserved SMC complex that uses its ATPase machinery to structure genomes, but how it does so is largely unknown. We show that condensin’s ATPase has a dual role in chromosome condensat

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p53 prohibits propagation of chromosome segregation errors that produce structural aneupoidies

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