Brentuximab Vedotin for Systemic Sclerosis (BRAVOS)
收藏NIAID Data Ecosystem2026-05-10 收录
下载链接：
https://immport.org/shared/study/SDY3216
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资源简介：
Diffuse cutaneous systemic sclerosis (dcSSc) remains a severe autoimmune condition with limited therapeutic options and high morbidity. This phase 1/2 multicenter, randomized, double-blind, placebo-controlled study will evaluate the safety and tolerability of brentuximab vedotin, an antibody–drug conjugate that targets CD30, a molecule expressed on activated T and B lymphocytes implicated in fibrotic and immune pathways of dcSSc. The trial uses a dose-escalation design with three ascending dose cohorts to establish safety parameters and inform future efficacy studies.
创建时间：
2025-10-30
