Data from: Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

Mapping hybrid defects in contact zones between incipient species can
identify genomic regions contributing to reproductive isolation and reveal
genetic mechanisms of speciation. The house mouse features a rare
combination of sophisticated genetic tools and natural hybrid zones
between subspecies. Male hybrids often show reduced fertility, a common
reproductive barrier between incipient species. Laboratory crosses have
identified sterility loci, but each encompasses hundreds of genes. We map
genetic determinants of testis weight and testis gene expression using
offspring of mice captured in a hybrid zone between M. musculus musculus
and M. m. domesticus. Many generations of admixture enables
high-resolution mapping of loci contributing to these sterility-related
phenotypes. We identify complex interactions among sterility loci,
suggesting multiple, non-independent genetic incompatibilities contribute
to barriers to gene flow in the hybrid zone.