scRNA-seq and bulk RNA-seq analysis of normoxic and hyperoxic lung in mice

To explore the key molecules and mechanisms involved in the occurrence and development of BPD by using a hyperoxia-based BPD model in neonatal mice, providing new ideas for discovering new therapeutic target to approach the clinical prevention and treatment for BPD. We performed whole transcriptome sequencing (RNA-seq) profiling analysis of lung endothelial cells from mouse normoxic or hyperoxic mice Comparative gene expression profiling analysis of RNA-seq data for normoxia and hyperxic mouse lung endothelial cells本研究通过构建基于高氧暴露的新生小鼠支气管肺发育不良（Bronchopulmonary Dysplasia, BPD）模型，探究参与BPD发生与发展过程的关键分子及作用机制，为发掘新的治疗靶点以推进BPD的临床防治工作提供新思路。本研究对常氧及高氧暴露小鼠的肺内皮细胞开展全转录组测序（RNA测序，RNA-seq）表达谱分析，并对两组小鼠肺内皮细胞的RNA-seq数据进行对比基因表达谱分析。