RNA sequencing analysis of shControl and shSASH1 in MDA-MB-468 cells. RNA sequencing analysis of shControl and shSASH1 in MDA-MB-468 cells

We performed RNA-seq to determine the impact of SASH1 depletion on global gene expression profile.The results reveal that dysregulated genes were enriched for genes related to cell adhesion, extracellular matrix (ECM) organization and cell migration, suggesting SASH1 may play a critical role in determining the invasion and metastasis phenotype in breast cancer cells. Overall design: Investigate transcriptomic difference between control and SASH1-depleted cells.