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The circadian clock components BMAL1 and REV-ERB? regulate flavivirus replication

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE123748
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We investigated the effect of the REV-ERB agonists on human hepatocytes. Since SR9009 showed the highest anti-viral activity and has been extensively studied in vivo we performed a whole genome microarray on SR9009 (20 µM) treated Huh-7 cells Two-condition experiment, Ctrl. vs. SR9009 treatment. Biological replicates: 3 control replicates, 3 treatment replicates.
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2018-12-14
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