Human microbiome characterization through massive shotgun sequencing of circulating cell-free DNA.
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Sequence data from cell free DNA found in 1351 blood samples collected from 188 patient was analyzed and assembled. 3761 of the 7190 larger contiguous regions generated were novel, with little or no homology to existing sequencing data. Presence of coding sequences in the contigs was confirmed in independent experiments and by direct PCR. The organisms identified represent entirely novel taxa, showing a substantially broader diversity in the human microbiome than previously appreciated.
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ImmPort创建时间:
2017-11-07



