Characterization of febrile disease landscape in Cambodia via metagenomic pathogen sequencing

Vector-borne diseases continue to cause significant global morbidity and mortality, particularly in Southeast Asia. However, given a lack of diagnostics available in resource-poor countries, many vector borne diseases are never diagnosed and therefore their impact is underappreciated. Cross sectional retrospective surveys have revealed higher than expected antibody prevalence to a number of diseases including mosquito-borne viruses and ectoparasite borne rickettsial diseases. Here, we aim to collect specimens from febrile individuals to better describe the febrile disease landscape of Cambodia using novel genomics technologies (unbiased next-generation sequencing) to investigate possible infectious etiologies of illnesses of unexplained etiology in Cambodian children and adults. With the current rise of vector-borne diseases around the world, we hope the results of this study contribute to better understanding the epidemiology and burden for vector-borne diseases in this region. Contact: Jessica E. Manning. This submission was powered by METAGENOTE (https://metagenote.niaid.nih.gov).