Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects. Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects
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下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA720937
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资源简介：
A mouse knock-in model engineered for Cre recombinase-activated expression of the endogenous mouse H3f3a allele generating an epitope-tagged H3.3 equipped with or without a K27M mutation to investigate H3.3 K27M effects on brain cell and tumor growth, gene expression and epigenetics. These samples are matched with H3K27me3 ChIPseq and RNAseq in GSE108364. Overall design: ChIP-seq for FLAG and H3K4me3 in neural stem cells from a mouse knock in model of H3f3a K27M (samples also appear in SuperSeries GSE108364).
创建时间：
2021-04-09
