Genome wide analysis of BCL3 mediated chemotherapy resistance
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE80729
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资源简介：
We identify the atypical inhibitor-κB protein, Bcl3, as a novel biomarker in gliomas whose expression level predicts response to therapy. Bcl3 is found at 19q13 and its expression level in glioma is regulated by copy number alteration. Mechanistically, Bcl3 mediates mesenchymal differentiation and its presence promotes resistance to cytotoxic DNA damage. The U87 cells was transfected with siRNA targeting BCL3 (dharmacon) or control siRNA, and followed by temozolomide treatment (100uM) for 24 hr before RNA extraction.
创建时间：
2018-10-22
