A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs - Underlying CT data

Underlying CT data of "A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs"

Paola Zgouro1, Orestis L. Katsamenis3,4, Thomas Moschakis5, Georgios K. Eleftheriadis6, Athanasios S. Kyriakidis6, Konstantina Chachlioutaki1,2, Paraskevi Kyriaki Monou1,2, Marianna Ntorkou7, Constantinos K. Zacharis7, Nikolaos Bouropoulos8,9, Dimitrios G. Fatouros1,2, Christina Karavasili1, Christos I. Gioumouxouzis1

1 Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece2 Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece3 μ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK4 Institute for Life Sciences, University of Southampton, University Rd, Highfield, Southampton, SO17 1BJ, UK5 Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece6 Pharmacare Premium Limited, R&D Department, HHF003 Hal Far Industrial Estate, Birzebbugia BBG3000, Malta7 Laboratory of Pharmaceutical Analysis, Department of Pharmacy, Aristotle University of Thessaloniki, GR-54124, Greece8 Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece9 Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, Greece

Microfocus Computed Tomography (μCT)

X-ray microfocus computed tomography (μCT) was employed for the characterization of the microstructure of the printed object, assessing the overall volume, porosity, local thickness and other printing defects. The imaging took place at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) / 3D X-ray Histology facility using a customized μCT scanner optimized for 3D X-ray histology (www.xrayhistology.org) (Katsamenis et al., 2023) based on Nikon’s XTH225ST system (Nikon Metrology, Castle Donington, UK). The scanner was operated at 110 kVp / 90 μA (9.9 W), with the X-ray beam prefiltered using 0.04 mm of aluminum. The source-to-object and source-to-detector distances were 28.4 mm and 1136.7 mm, respectively, resulting in a magnification factor of 40x. Acquisition parameters included 2201 projections, averaging 4 frames per projection, with an exposure time of 177 ms per projection. The 2850 x 2850 dexels detector was binned 2x (virtual detector: 1425 × 1425 dexels), resulting in an isotropic voxel edge of 7.5 μm. The reconstructed data underwent visualization and analysis using Dragonfly software (Comet Technologies Canada Inc.; software available at http://www.theobjects.com/dragonfly).