Cognitive functioning: WASI in Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women, PH100

Wechsler Abbreviated Scales of Intelligence (WASI), administered to either child or caregiver
Study Description
The PHACS Surveillance Monitoring for ART Toxicities (SMARTT) Study was designed to identify potential adverse effects of ARV exposures in infants born to women with HIV infection, and to evaluate associations with ARV combinations and specific ARV drugs in order to help inform treatment guidelines for HIV-infected pregnant women. SMARTT follows two cohorts of HIV- and ART-exposed but uninfected children: the Static and Dynamic cohorts. Domains of interest include birth outcomes, growth, metabolic, cardiac, neurological, neurodevelopmental, behavior, language, and hearing. Biospecimens are available. SMARTT participants include a Static cohort (n=1240) enrolled at age 1-12 years, a Dynamic cohort (n=1016) enrolled during gestation or < 1 week after birth, and a Reference cohort (n=239) of 50-60 children enrolled at each of ages 1, 3, 5, and 9 years.