IL-17A and IL-22 can activate human gastrointestinal epithelial cells to kill H. pylori.

The ability of H. pylori to survive for 6 hours in co-culture with AGS cells pre-stimulated for 16 hours with IL-22, IL-17A or combined IL-22 and IL-17A is presented. (A) SS1 strain or (B) PMSS1 strain percent (%) survival represented on the y-axis is equal to the number of H. pylori CFU from the cytokine-treated cells divided by the number of CFU recovered from untreated AGS cells. Graphs are representative of 3 independent experiments and error bars represented mean ± SEM. Statistical significance is based on one-way ANOVA test with Dunnett’s correction for multiple comparisons to the no cytokine treatment control ***p