Expression pattern of circRNA in primary and recurrent glioblastoma.. Expression pattern of circRNA in primary and recurrent glioblastoma.

Circular RNAs are single-stranded covalently closed non-coding RNAs expressed in a variety of tissues and cells. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. Here we explore circRNA expression profiles in 26 primary and 3 recurrent GBM samples and compare them to healthy brain tissue. Additionally we compare expression of circRNA in GBM patients blood in comparison to healthy donor blood. Overall design: CircRNA expression profiles in 26 primary and 3 recurrent GBM samples in comparison to healthy brain tissue RNA libraries. Additionally expression profiles of circRNAs in GBM patients blood (n=3) in comparison to healthy donors blood (n=4)