Identification of the RB loss-induced E2F1 cistrome in prostate cancer [ChIP-seq]. Homo sapiens

The retinoblastoma protein (RB) is preferentially lost in the progression to castrate resistant prostate cancer (CRPC). However, the alterations associated with such loss have been scantly described. The current study aims to provide molecular mechanisms underlying Rb loss-driven CRPC phenotypes. Overall design: Alterations in E2F1 binding upon RB loss were assessed in hormone deficient conditions through ChIP-Seq of shCON and shRB LNCaP prostate cancer cells.