Mechanisms associated with pluripotency

The aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we intentionally focused on information flow, neglecting reactions, metabolites, intracellular movement of components, and their modifications such as protein phosphorylation Each edge can be seen as direct mechanism between its nodes. For more information, see Som A, Harder C, Greber B, Siatkowski M, Paudel Y, et al. 2010 The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications. PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015165 The June 2010 PluriNetWork described in the paper can be found at http://www.ibima.med.uni-rostock.de/IBIMA/PluriNetWork/ . The PluriNetWork at WikiPathWays started with the December 2010 version.

PluriNetWork旨在对小鼠多能性相关的特定机制进行概述。每个节点代表一个基因及其相应的蛋白质产物。正如所述，我们有意关注信息流，而忽略反应、代谢物、组分在细胞内的运动及其修改，例如蛋白质磷酸化。每条边可以被视为其节点之间的直接机制。更多详细信息，请参阅Som A, Harder C, Greber B, Siatkowski M, Paudel Y, 等人于2010年发表的《The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications》。PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015165。文中描述的2010年6月的PluriNetWork可在http://www.ibima.med.uni-rostock.de/IBIMA/PluriNetWork/找到。WikiPathWays上的PluriNetWork始于2010年12月版本。