a compared to lin-17(n671) b compared to lin-17(n671); gfp(RNAi) c compared to lin-18(e620) d compared to lin-18(e620); gfp(RNAi) Animals were grown at 23°C and scored by DIC at late L4 stage. n is nu

NIAID Data Ecosystem50

Synthetic lethal screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition. Synthetic lethal screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition

合成致死筛选

ATRX突变癌症靶向治疗

we performed a genome-wide synthetic lethal screen, using CRISPR-Cas9 genome editing, to identify potential therapeutic targets specific for ATRX-mutated cancers. In isogenic hepatocellular carcinoma

NIAID Data Ecosystem30

Genetic interactions between <i>ulp2</i>Δ and <i>rad52</i>Δ mutants.

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