Association of age, diabetes duration, and sex with severe hypoglycemia and hypoglycemic coma for 1995–2012, expressed as relative risk and annual change in relative risk.

Results derived from regression models with severe hypoglycemia or hypoglycemic coma as the dependent variable, adjusted for treatment year (continuous term), HbA1c (continuous term), sex, age, and diabetes duration, and with a term for interaction between treatment year and HbA1c. p-Values from Wald tests refer to RRs. For assessment of changes in the association of variables with severe hypoglycemia and hypoglycemic coma between treatment years, regression models additionally included terms for interactions between treatment year by age, diabetes duration, and sex.*Additionally adjusted for insulin treatment regimen (1–3 or ≥4 insulin injection time points per day, or insulin pump therapy).§Estimate represents the average annual change in RR (corresponds to a term for interaction with treatment year in models; p-values from Wald tests).Association of age, diabetes duration, and sex with severe hypoglycemia and hypoglycemic coma for 1995–2012, expressed as relative risk and annual change in relative risk.