Supporting data for "Radix Rehmanniae and Active Ingredients Ameliorate CFA-Induced Inflammation by Attenuating Macrophage-Mediated Localized Response and Nitrative Damage"

This research highlights that macrophage-induced inflammation leads to localized nitration and assembly, contributing to tissue damage and inflammatory cell infiltration in OA pathogenesis. Targeting macrophage-mediated inflammation offers a promising OA therapeutic strategy. RR and its active ingredients show potential as therapeutic agents to alleviate macrophage-mediated localized inflammatory microenvironments and nitrative damage in OA treatment.Further investigations are warranted to comprehend the precise mechanisms and clinical applicability of RR and its active compounds in managing inflammatory pain and OA.