The effects of Candida albicans on the metastatic activity of oral squamous cell carcinoma. The effects of Candida albicans on the metastatic activity of oral squamous cell carcinoma

The effects of Candida albicans on the metastatic activity of oral squamous cell carcinoma was observed in vitro and in vivo. In the in vitro experimental setup HO-1-N-1 and HSC-2 human oral squamous cell carcinoma cell lines were treated with zymosan, heat-killed Candida albicans, heat-killed C. parapsilosis, live C. albicans and live C. parapsilosis. Whole transcriptomics was performed of the human tumor cells. In the in vivo experiment human HSC-2 tumor cells were injected to the tongue of mice. Whole transcriptomic analysis was performed of the human HSC-2 derived tumor cells comparing control tumor and oral candidiasis treated tumor. Overall design: in vitro: 2 OSCC cell lines untreated or treated with 5 different treatments. in vivo: 4 control tumors, 4 oral candidiasis-treated tumors.