Obesity and Race Alter Gene Expression in Skin. Obesity and Race Alter Gene Expression in Skin

We studied differences in epithelial thickness by histology and gene expression by Affymetrix gene arrays and PCR in the skin/fat of 10 obese (BMI 35-50) and 10 normal weight (BMI 18.5-26.9) postmenopausal women paired by age and race Overall design: Skin and fat biopsies were collected from 20 subjects (10 obese, 10 normal wight). Biopsies were evaluated by immunohistochemical staining, and gene expression profiling with Affymetrix U133 2.0Plus arrays and RT-PCR.