Altered TE-derived genes leads to pathogenesis of FXD [PacBioRNASeq]

We identified known and unknown transposon elements in the cells from healthy donors, FXD patients, and ALL patients by long-read RNA-sequencing. Using these identified TEs, we analyzed the expression of TE-derived genes by shot-read (illumina) RNA-sequencing. We found that expression of some specific TE-derived genes were changed in FXD compared to those in healthy donors. These findings suggested the involvement of modified expressions of TE-derived genes in the pathogenesis of FXD. Overall design: We analyzed total RNA and mRNA in 8 kinds of healthy donors' cells, 9 kinds of FXD patients' cells, and 4 kinds of ALL patients' cells.