T cell-specific RIPK1 ablation results in villus atrophy of the duodenum in mice

RIPK1 is required in T cells with a history of CD4-expression to maintain intestinal homeostasis. We show that the pathology in the upper intestine is a result of conventional T cell apoptosis in absence of the RIPK1. Four samples in total: Two intraepithelial lymphocytes (IEL) samples: Ripk1FL/FL and Ripk1CD4; Two lamina propria lymphocytes (LPL) samples: Ripk1FL/FL and Ripk1CD4受体相互作用蛋白激酶1（Receptor-interacting protein kinase 1, RIPK1）对于具有CD4表达史的T细胞维持肠道稳态不可或缺。本研究证实，上肠道的病理改变系RIPK1缺失时常规T细胞凋亡所致。本次数据集共包含四组样本：两组上皮内淋巴细胞（intraepithelial lymphocytes, IEL）样本，分别为Ripk1FL/FL与Ripk1CD4；两组固有层淋巴细胞（lamina propria lymphocytes, LPL）样本，分别为Ripk1FL/FL与Ripk1CD4。