Supplementary Material for: Rectal neuroendocrine tumor presenting as refractory chronic pruritus ani: a case report

Primary neuroendocrine tumors (NETs) of the rectum are rare and often present with nonspecific gastrointestinal symptoms, making early diagnosis challenging. We report the case of a 42-year-old male with persistent pruritus ani and mild rectal bleeding refractory to conventional treatment, ultimately diagnosed with a well-differentiated Grade 1 rectal NET. This case underscores the importance of maintaining clinical suspicion for rare malignancies when evaluating persistent anorectal symptoms and highlights the critical role of thorough endoscopic evaluation in achieving early diagnosis and favorable outcomes.