scRNA-seq of human fibroblasts reprogrammed into neurons via PTBP1 downregulation

In this study, we investigate the cellular heterogeneity and transcriptional dynamics underlying directneuronal reprogramming in human dermal fibroblasts via PTBP1 downregulation. By integratingsingle-cell RNA sequencing with trajectory-based gene expression and pathway analyses, wedelineate distinct differentiation pathways and uncover key transcriptional regulators associated withneuronal maturation.