Targeting KDM4A epigenetically activates tumor cell-intrinsic immunity and overcomes resistance to PD1 blockade in squamous cell carcinoma by inducing DNA replication stress
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137953
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To investigate the mechanisms by which KDM4A knockout ameliorates the invasive growth and metastasis of primary mouse squamous cell carcinoma (SCC), we isolated fresh SCCs from tumor cell-specific KDM4A knockout and control mice, and then did the whole transcriptome analysis using RNA-Seq. Results showed that KDM4A knockout stimulated anti-tumor immunity. Analysis of the whole transcriptome of primary mouse SCCs.
创建时间：
2021-03-23
