Single nuclei multiome analysis in the human substantia nigra from diverse individuals with DLB and PD

Fully integrated multiome object of 177 human post-mortem samples of the substantia nigra. Multiome object is here as a muon object, which contains gene expression in the 'rna' modality, chromatin accessibility along consensus peaks in the 'atac' modality, and inferred transcription factor motif activity in the 'chromvar' layer. Consensus peaks were generated from cell type specific chromatin accessibility, which were generated from pseudobulking ATAC fragments by cell type and using MACS2 to infer peaks. This dataset was processed using the scMAVERICS pipeline, with the version used for this analysis on the 'SN' branch https://github.com/NIH-CARD/scMAVERICS/tree/SN.