Next-generation sequencing of human monocyte-derived dendritic cells stimulated with sialic acid glycodendrimers in the absence or presence of LPS

To investigate whether a2-3 sialic acid dendrimers that bind to Siglec-9 would alter signalling and reprogramming of human monocyte-derived dendritic cells with and without LPS. 24 samples were included in next-generation sequencing, including triplicates for control moDCs, control glycodendrimer, alpha2-3 sialic acid glycodendrimer and a2-6 sialic acid glycodendrimers, all-in the absence or presence of LPS. The control dendrimers and control dendrimers in the presence of LPS serve as reference samples.