Association of the three index SNPs with macrovascular diseases.

SE: standard error, OR: odds ratio, N: number of incident events, HR: hazards ratio, WTCCC: Wellcome Trust Case Control Consortium, CAD: Coronary Artery Disease, HVH: Heart and Vascular Health Study, MI: Myocardial infarction, Global BPGen: Global Blood Pressure Genetics Consortium; HTN: hypertension, GoDARTS: Genetics of Diabetes Audit and Reseach Tayside Scotland.The allele that decreases retinal arteriolar caliber is presented as the effective allele (refer to Table 2).*excludes cardioembolic stroke.‡adjusted for age, gender, BMI, history of smoking and hypertension medication.†adjusted for age, gender, BMI, history of smoking, previous CAD events and previous ischaemic stroke events.