BIOGRID CURATED DATA FOR GYP5 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for GYP5 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication

由BioGRID（https://thebiogrid.org）精心编制的GYP5（酿酒酵母S288c）蛋白-蛋白、遗传和化学相互作用数据集；定义：酵母Rab家族成员的GTPase激活蛋白（GAP），参与内质网到高尔基体的运输；对Ypt1p表现出GAP活性，该活性由Gyl1p刺激，亦作用于Sec4p；与Gyl1p、Rvs161p和Rvs167p相互作用；在极性生长过程中参与将Rvs167p招募至芽尖；在DNA复制压力下从芽颈重新定位至细胞质；GYP5具有一个同源蛋白GYL1，该蛋白源于全基因组复制。