Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system [smRNA-seq]

To investigate the expression of miRNA/mRNA regulatory networks in a developmental cohort of C57Bl/6 mice. This submission is the miRNA sequencing dataset. Sequenced the miRNAome and mRNAome of primary mouse microglia during brain development and adult homeostasis (three age groups; P6, P15 and 8 weeks). Sequenced and compared small RNA expression in both CD45+ microglial cells and CD45- bulk CNS cells in each sample. mRNA expression was sequenced in CD45+ microglial cells.本研究旨在探究C57Bl/6小鼠（C57Bl/6 mice）发育队列中miRNA/mRNA调控网络的表达特征。本次提交的数据集为miRNA测序数据集：针对脑发育及成年稳态阶段的原代小鼠小胶质细胞（primary mouse microglia），对其miRNA组（miRNAome）与mRNA组（mRNAome）开展测序，实验共设置三个年龄组别：出生后第6天（P6）、出生后第15天（P15）以及8周龄。此外，本研究对每一份样本中的CD45阳性（CD45+）小胶质细胞与CD45阴性（CD45-）中枢神经系统（Central Nervous System, CNS）整体细胞群的小RNA表达进行测序与对比；同时对CD45+小胶质细胞的mRNA表达进行了测序。