RNA-seq data of metformin treated MDA-MB-231 cells
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP417233
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Our previous studies in Triple-Negative Breast Cancers (TNBCs) have demonstrated high fatty acid Beta-oxidation (FAO) and Electron Transport Chain (ETC) dependency to activate Src kinase by the Y419 autophosphorylation of Src. Higher doses of metformin have been shown to directly inhibit complex I of ETC. Here, analysis of RNA-seq data upon treatment with high concentration of metformin reveals inhibition of various oncopathways including the Src kinase pathway. Our study identifies a clinically relevant therapeutic approach to better manage poorly-targetable TNBCs. Overall design: two group comparison
创建时间：
2025-03-05
