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Spectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma

ChEBI2014-02-19 更新2026-07-21 收录

黑色素瘤耐药性

BRAF抑制剂临床研究

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-50509 数据链接链接失效反馈

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Spectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma

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2014-02-19

黑色素瘤耐药性

RAS突变肿瘤

Targeted therapies have the potential to revolutionize cancer care by providing personalized treatment strategies that are less toxic and more effective but it is clear that for most solid tumors supp

NIAID Data Ecosystem70

Proteomics identifies markers of MAPKi resistance offering new therapeutic strategies in melanoma- Cytoplasmic (cyt), nuclear (ne) and secreted (sn) proteins of MAPKi sensitive melanoma cells

黑色素瘤耐药性

蛋白质组学生物标志物

MAPK inhibitors (MAPKi) show outstanding clinical response rates in melanoma patients harbouring BRAF mutations, but resistance is common. High-throughput, subcellular proteome analyses at two differe

NIAID Data Ecosystem60

Additional file 3 of Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK

黑色素瘤耐药性

PI3K磷脂酰肌醇3-激酶

Additional file 3: Supplementary Table S3: Variants of genes encoding class I PI3K regulatory subunits

Figshare2021-02-06 更新30

CRISPR screens identify tumor-promoting genes conferring melanoma cell plasticity and resistance

黑色素瘤耐药性

CRISPRi筛选

Most genetic alterations that drive melanoma development and resistance to targeted therapy have been uncovered. In contrast, and despite their increasingly recognized contribution, little is known ab

NIAID Data Ecosystem60

Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma

黑色素瘤耐药性

RNA修饰机制

We performed RNA-seq to analyse the different expression genes of DTIC-resistant (DR) A375 cells and wild-type control. Examination of differentially expressed genes in DR A375 cells compared with wil

NIAID Data Ecosystem50

Spectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma

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