Results of SNP-metabolite association analyses.

Table includes all validated loci of our analysis. Validation is based on either successful replications in the Sorbs or by additional published evidence. The latter applies for two loci (#4 and #14) where association of lead-SNPs did not replicate in the Sorbs cohort. For each locus, nearby genes, independently associated SNPs, associated metabolites and statistics for the strongest association between them are shown (Beta estimators, corresponding standard errors and p-values). We also present the results of replication analysis and published evidence. Six loci with no corresponding published genetic variants were considered as “novel”.1SNP with strongest association in the discovery cohort is presented in bold;2Distance of SNPs to genes in kB in parentheses;3Metabolite with strongest association in the discovery cohort is presented in bold. p-value Sorbs: best p-value of SNPs in Sorbs corresponding to the lead-SNP and metabolite of discovery cohort,4Replication was successful for ratio Q14:Arg/Orn, only, hence, we report here on association with Q14:Arg/OrnResults of SNP-metabolite association analyses.