Additional file 1 of Clinical characteristics and genetic spectrum of 26 individuals of Chinese origin with primary ciliary dyskinesia
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https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Clinical_characteristics_and_genetic_spectrum_of_26_individuals_of_Chinese_origin_with_primary_ciliary_dyskinesia/14897260/1
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Additional file 1. The gene list of known 51 PCD genes and 42 suspected PCD genes. 93 PCD candidate genes are listed in the Excel file, including 51 known genes and 42 suspected ones. Fifty-one known PCD-causative genes were retrieved from OMIM and PubMed, and forty-two suspected genes were selected based on all of the following features: (1) belong to the same gene family as known PCD pathogenic genes; (2) have high expression in lung and testis tissues, where motile cilia are abundant, either for mucus expelling or for sperm motility; (3) encode a ciliary structural protein or a functional composition of motile cilia, such as proteins associating with intraflagellar transport (IFT) or cilia stability and assembly.
提供机构：
Xu, Kai-Feng; Xu, Wenshuai; Liu, Keqiang; Zhao, Xinyue; Tian, Xinlun; Bai, Jing; Liu, Yaping; Bian, Chun; Zhang, Xue
创建时间：
2021-07-02
