Increased vulnerability to atrial and ventricular arrhythmias caused by different types of inhaled tobacco or marijuana products

Background: The emergence of a plethora of new tobacco products marketed as being less harmful than smoking, such as electronic cigarettes and heated tobacco products, and an increased popularity of recreational marijuana, has raised concerns about the potential cardiovascular risk associated with their use.
Objective: The present study aimed to investigate whether the use of novel tobacco products or marijuana can cause the development of proarrhythmic substrate and eventually lead to arrhythmias.
Methods and results: Rats exposed to smoke from tobacco, marijuana, or cannabinoid-depleted marijuana, or to aerosol from electronic cigarettes or heated tobacco products, once per day for 8 weeks exhibited progressively increased systolic blood pressure, decreased cardiac systolic function with chamber dilation, and reduced overall heart rate variability, relative to the clean air negative control group. Atrial fibrillation and ventricular tachycardia testing by ex vivo optical mapping rev...