<b>Figure 2. </b><b>Experimental design for inoculating </b><b>α</b><b>-synuclein pre-formed fibrils in M83 mice </b><b><i>in vivo</i></b>.
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<b>(B)</b> Brain homogenates from aSyn PFF-1 and PFF-2 inoculated mice both displayed resistance to proteinase K but exhibited variable banding patterns upon digestion, as assessed by Western Blot using an antibody for total aSyn. <b>(C)</b> Brain homogenates from aSyn PFF-1 and PFF-2 inoculated mice were evaluated by dotblots using an antibody with high affinity for aggregated aSyn (chBIIB054), revealing that while both fibril types exhibited significant binding, aSyn PFF-2 brain homogenates presented with a stronger signal.<br>
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2025-12-22
