As an important part of the comprehensive treatment methods, the urate-lowering Chinese herbs could provide favorable clinical effects on hyperuricemia in its ability to invigorate spleen and remove d

NIAID Data Ecosystem40

Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

肝损伤机制

代谢物研究

Two 2-aminoimidazole-based inhibitors, LY3031207 (1) and LY3023703 (2), of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme were found to cause drug-induced liver injury (DILI) in humans. We

Figshare2018-02-15 更新20

The pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury. Canis lupus familiaris

肝损伤机制

生物疾病模型

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the treatment of arthritis and chronic pain associated with musculoskeletal injuries. However, its use is associated with

NIAID Data Ecosystem60

DataSheet_1_Susceptibility to Infections During Acute Liver Injury Depends on Transient Disruption of Liver Macrophage Niche.docx

器官免疫微环境

肝损伤机制

Kupffer cells are the primary liver resident immune cell responsible for the liver firewall function, including clearance of bacterial infection from the circulation, as they are strategically positio

NIAID Data Ecosystem30

Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation

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