NCOA1
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1319167
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资源简介：
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
该基因编码的蛋白质充当类固醇和核激素受体的转录共激活因子。它属于p160/类固醇受体共激活因子（SRC）家族，与其他家族成员类似，具有组蛋白乙酰转移酶活性，并含有核定位信号、bHLH和PAS结构域。该基因产物能够直接结合核受体，并在激素依赖性的方式下刺激转录活性。此外，已鉴定出不同剪接形式的转录变体，编码不同的异构体。[由RefSeq提供，2008年7月]
提供机构：
Rat Genome Database
