A novel function for Myc: inhibition of C/EBP-dependent gene activation.
收藏PubMed Central1996-06-25 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC39078/
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资源简介：
We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc downregulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc, but not its DNA-binding domain, are required for the suppression of C/EBP-dependent transactivation. Our findings identify a new function for Myc and reveal a novel mechanism by which Myc affects the expression of other genes. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-06-25
