Whole transcriptomics analysis of lacrimal gland during chronic inflammation progression.

To identify the molecular pathways altered during the progression of chronic inflammation in the lacrimal gland, we compared the transcriptome of NOD.B10.H2b vs BALB/cJ mice at different time points We sequenced RNA from lacrimal glands of BALB/cJ (control) and NOD.H2b (disease) mice aged of 2, 4 and 6 months in triplicates.为鉴定泪腺慢性炎症进展过程中发生改变的分子通路，本研究对不同时间点的NOD.B10.H2b小鼠与BALB/cJ小鼠的转录组（transcriptome）进行了比较分析。我们分别提取2、4、6月龄BALB/cJ（对照组）与NOD.H2b（疾病模型组）小鼠的泪腺组织RNA进行测序，每个组别设置三次生物学重复。