Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-1
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Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-1 Descriptor: 1,2-ETHANEDIOL, 4-[bis(4-chlorobenzyl)amino]-N-hydroxybutanamide, Botulinum neurotoxin type A, ... Authors: Thompson, A.A, Han, G.W, Stevens, R.C. Deposit date: 2011-01-28 Release date: 2011-04-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility. Biochemistry, 50, 2011
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2011-01-28
