Data for: Pitfalls of NMDA receptor modulation by neuroactive steroids
收藏doi.org2025-03-26 收录
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http://doi.org/10.17632/5bg2z4hrdw.2
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Data set contains data from a battery of tests - open field, elevated plus maze, passive avoidance, prepulse inhibition and carousel maze experiment.
We evaluated antipsychotic potential of two neuroactive steroids in an animal model of schizophrenia induced by systemic MK-801 application. Neuroactive steroid differed from each other by their effect on NMDA receptors. PA-Glu potentiated while MS-249 inhibited NMDA receptors.
本数据集汇聚了多种实验测试数据，包括开阔场地测试、升高加迷宫测试、被动回避测试、预备脉冲抑制测试及旋转迷宫实验。本研究旨在评估两种神经活性类固醇在由系统应用MK-801诱导的动物模型中抗精神分裂症潜能。两种神经活性类固醇在影响NMDA受体方面存在差异：PA-Glu可增强NMDA受体活性，而MS-249则抑制NMDA受体。
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