Virtual screening identifies tipranavir as a SIRT1 inhibitor with anti-hepatocarcinoma effect - Supplementary files.docx

<strong>Supplementary Table 1. Key resources table of antibodies, chemicals and assay kits</strong>

Figure S1. Time evolution plot of root mean square deviation (RMSD) of compound <strong>6148</strong> (black) and SIRT1-<strong>6148</strong> complex (red).
 Figure S2. Time evolution plot of root mean square deviation (RMSD) of compound <strong>974</strong> (black) and SIRT1-<strong>974</strong> complex (red) 
 Figure S3. Time evolution plot of root mean square deviation (RMSD) of compound <strong>952</strong> (black) and SIRT1-<strong>952</strong> complex (red) 
 Figure S4. Time evolution plot of root mean square deviation (RMSD) of compound <strong>938</strong> (black) and SIRT1-<strong>938</strong> complex (red)
 Figure S5. Time evolution plot of root mean square deviation (RMSD) of compound <strong>932</strong> (black) (tipranavir) and SIRT1-<strong>932</strong> complex (red)
 Figure S6. Time evolution plot of root mean square deviation (RMSD) of compound <strong>929</strong> (black) and SIRT1-<strong>929</strong> complex (red)
 Figure S7. Time evolution plot of root mean square deviation (RMSD) of compound <strong>923</strong> (black) and SIRT1-<strong>923</strong>complex (red)
 Figure S8. Time evolution plot of root mean square deviation (RMSD) of compound <strong>918</strong> (black) and SIRT1-<strong>918</strong> complex (red)
 Figure S9. Time evolution plot of root mean square deviation (RMSD) of compound <strong>867</strong> (black) and SIRT1-<strong>867</strong> complex (red). 
 Figure S10. Time evolution plot of root mean square deviation (RMSD) of compound <strong>863</strong> (black) and SIRT1-<strong>863</strong> complex (red)
  Figure S11. Time evolution plot of root mean square deviation (RMSD) of compound <strong>EX527 </strong>(black) and SIRT1-<strong>EX527</strong> complex (red).